This is a common memory issue with RPG Maker's DirectX renderer.
When you upscale 640x480 to 1920x1080, the image gets soft. You don't want anti-aliasing; you want sharp pixels . fullscreen pokemon insurgence
: Using this method may occasionally cause the mouse cursor to become misaligned with on-screen buttons, requiring you to click slightly above or below your intended target. In-Game Options Menu This is a common memory issue with RPG