To understand the weight of Resident Evil: Damnation , one must understand where it sits in the timeline. Unlike the live-action films which created an alternate universe featuring an overpowered Alice, the CG films are canon to the game timeline.
The climax is a three-way war between:
While the rebels see the monsters as their only hope for freedom, Leon sees the inevitable: the Plaga doesn't just obey; it consumes. Sasha, already infected to maintain control over his "pets," is slowly losing his humanity to the parasite nesting in his spine. The Tyrant's Descent Resident Evil Damnation Full