You cannot run TotK on Yuzu without mods. Even with the best cache, the vanilla game will crash.
This usually means your is struggling. Try clearing your cache and ensuring you are using the latest "Early Access" or "Mainline" build of Yuzu, as TotK optimizations are added frequently. Zelda Totk Shader Cache Yuzu-
If you have tried running The Legend of Zelda: Tears of the Kingdom (TotK) on the Yuzu emulator, you have likely encountered the dreaded "stutter." You are exploring the sky islands, the game is running at a smooth 60 frames per second, and suddenly—. The screen hangs for half a second, the audio glitches, and then everything resumes. You cannot run TotK on Yuzu without mods