, titled "The Clash of Red and Black: The Beginning" (Japanese: "Akai to Kuro no Clash: Hossoku"), is one such milestone. It serves as the explosive opening to one of the most celebrated arcs in the anime's history: The Clash of Red and Black.
Eisuke explains that his sister once saved his life with a blood transfusion. However, a major inconsistency arises: Eisuke has Type O blood , meaning he can only receive Type O. Later investigations reveal Rena Mizunashi is Type AB , casting doubt on whether they are truly siblings or if there is a deeper secret to Eisuke's past. Detective Conan Episode 491
The episode opens not with a murder in a locked room, but with a medical emergency. A man named (the high school student, not to be confused with his sister) collapses on a Tokyo street and is rushed to Haido Central Hospital . He is suffering from a severe gunshot wound. , titled "The Clash of Red and Black:
, titled "Clash of Red and Black: The Beginning" (赤と黒のクラッシュ 始まり), is a pivotal installment in the long-running Detective Conan (Case Closed) anime. Originally broadcast on January 14, 2008, it serves as the foundational episode for the "Clash of Red and Black" arc, which remains the longest and arguably most intense storyline in the series' history. Context and Significance However, a major inconsistency arises: Eisuke has Type
Episode 491 brilliantly showcases Conan’s unique position. He is not an FBI agent or a CIA operative. He is a child. This allows him to move freely where adults cannot. He eavesdrops on FBI strategy sessions, passes notes to Jodie, and even confronts Subaru Okiya in a seemingly innocent conversation. His internal monologue is frantic—he realizes they are trapped in a “cage” of the Organization’s design.
Detective Conan Episode 491 "Clash of Red and Black (Beginning),"
Watch these consecutively for the full story: