This is distinct from a "Missing DLL" error. If the file were missing, the game wouldn't know where to look. In this case, the game finds the file, opens it, realizes it doesn't have what it needs, and shuts down.
Go to the tab and right-click Prototype2.exe (while the game is attempting to launch). Error Dll Prototype2engine.dll Does Not Contain Required
Start with Fix 2. For 80% of users, that will launch the game instantly. For the remaining 20%, combining file verification and overlay disabling will resolve the issue. Prototype 2 is a classic title that deserves to be played without technical frustration. Follow this guide, and you will be slashing through infected Manhattan in under ten minutes. This is distinct from a "Missing DLL" error