failed open file "nativePC...\some.arc"
Errors during startup are often tied to display settings that the game cannot properly initialize. Navigate to %USERPROFILE%\Documents\CAPCOM\RESIDENT EVIL 6\ config.ini with Notepad. and set it to resident evil 6 fatal error failed open file
Resident Evil 6 was released in a time when Windows User Account Control (UAC) was less aggressive than it is today. Modern Windows 10 and 11 systems often restrict games from writing to specific folders (like the Documents folder) unless explicitly authorized. If the game tries to write a save file and is blocked, it will trigger a "Fatal Error." failed open file "nativePC
The message might show something like: